chlamydia pneumonia and proliferative diabetic retinopathy: serologic evidences in a pilot study

نویسندگان

توکا بنایی

touka banaee مجید ابریشمی

majid abrishami رامین دانشور کاخکی

ramin daneshvar-kakhki سیامک مرادیان

siamak zarei-ghanavati محمود محمودی

چکیده

purpose : chlamydia pneumonia is a known endothelial pathogen in several vascular diseases including atherosclerosis, age-related macular degeneration and non-arteritic anterior ischemic optic neuropathy. diabetic retinopathy is a retinal vascular disease that may similarly be affected. we serologically investigated the presence of c. pneumonia infection in patients with proliferative diabetic retinopathy. design : pilot case-control study. patients & methods : during a period of 12 months, we examined sera of 27 type i diabetic patients with different stages of diabetic retinopathy for anti-chlamydial igg and iga by enzyme-linked immunosorbent assay (elisa). results : the igg seropositivity was significantly different between different diabetic retinopathy groups (p=0.017). rate of seropositivity was higher among patients with pdr comparing to patients without pdr, with a marginal significance (p=0.062). although the titer of iga was negative in all patients (less than 0.357 u/ml), the iga titer was higher in patients with pdr than those without pdr, reaching the significance at p<0.06 level. conclusion : c. pneumonia may be an independent risk factor for proliferative diabetic retinopathy.   iranian journal of ophthalmology 2006 19(2):19-26

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عنوان ژورنال:
journal of current ophthalmology

جلد ۱۹، شماره ۲، صفحات ۱۹-۲۶

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